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Data from Israel suggest a slight additional benefit of the fourth dose of vaccine in protecting against Omicron infection. The fourth dose of an mRNA vaccine restored antibody levels among healthcare workers similar to those seen shortly after the booster. Still, breakthrough infections were expected, according to a paper not yet reviewed by external experts.
The effectiveness of the fourth dose in terms of protection against infection with the Omicron variant is reported by researchers to be 11 percent (Moderna) to 30 percent (Biontech) compared to triple vaccinated individuals. Because of the hypothesized effect against severe illness and death, older and vulnerable groups are most likely to benefit from a fourth dose, according to the authors.
According to the study, the courses among infected healthcare workers were mainly very mild, but most of them had relatively high viral loads. They were potentially contagious, according to the authors. In their conclusion, the team wrote that the low effectiveness of the fourth dose in preventing mild or asymptomatic omicron infections and the potential for infection among those affected increased the urgency of developing next-generation vaccines. Overall, the data suggested that a fourth dose does not additionally boost immunity but restores peak levels, they say.
- source:. derstandard.at/picture:pixabay.com
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