Massive Study Reveals True Effectiveness of COVID-19 Vaccines

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The debate over COVID-19 vaccines continues years after the pandemic began. A new long-term study now provides crucial scientific insights into how effective mRNA vaccines truly were and what impact they had.

Researchers led by Laura Semenzato from France’s drug safety authority analyzed data from more than 28 million people. The study compared 22.7 million vaccinated individuals with 5.9 million unvaccinated people aged 18 to 59 over nearly four years (November 2021 to September 2025). By statistically balancing the two groups, the researchers ensured reliable conclusions about benefits and risks. The findings were published in JAMA Network Open.

Fewer Deaths

One of the central results: vaccination significantly reduced the risk of severe COVID-19 and related deaths. Vaccinated individuals had about a 74% lower risk of dying from severe COVID-19 compared to the unvaccinated. Per million unvaccinated people, 85 died from COVID-19, while among the vaccinated, only 18 per million succumbed.

This confirms that the mRNA vaccines Comirnaty (BioNTech/Pfizer) and Spikevax (Moderna) achieved their primary goal—preventing severe illness and saving lives—even years after their initial approval.

Overall Mortality

Another striking finding: vaccinated individuals did not face higher overall mortality. In fact, their risk of dying from any cause was about 25% lower. This pattern held across major causes of death, including cancer and cardiovascular disease. Across all categories, vaccinated groups consistently showed fewer deaths per million than unvaccinated groups.

Remarkably, the vaccinated population tended to be older and more likely to have pre-existing conditions—factors usually linked to higher mortality. Despite this, no increase in deaths was observed among them. Researchers suggest that better access to healthcare and greater health awareness among vaccinated individuals may have contributed to these outcomes.

Conclusion

The authors conclude that mRNA vaccines are both effective and safe in the long term. They substantially reduce severe COVID-19 cases and deaths, while also lowering overall mortality. These findings underscore that mRNA vaccines were a vital and beneficial tool in managing the pandemic.

Independent epidemiologists not involved in the study agree: the data is robust and comprehensive enough to confirm the protective effects of vaccination.

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