Biontech or Moderna: Differences in the effect against Delta?

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A new study shows a greater decline in efficacy with Biontech/Pfizer than with Moderna. Experts stress, however, that the last word has not yet been spoken.

All Covid 19 vaccines protect well against severe disease, including the Delta variant. This is undisputed among experts. Recently, for example, a survey by the news magazine Profil showed that the majority of Corona patients in intensive care units are unvaccinated. And international experience shows: Those who have a severe course of disease despite double vaccination (or single vaccination in the case of Johnson & Johnson’s preparation) are usually affected by serious pre-existing conditions.

But in detail, there are obviously differences in the overall protection against infection. Scientists in the United States have compared how well the mRNA vaccines from Biontech/Pfizer and Moderna protect against infection, Spiegel online reports. Both vaccines were highly effective against SARS-CoV-2 infection and Covid-19-associated hospitalizations during the study period from January to July 2021, Spiegel online quotes from a study not yet reviewed by independent experts.

The risk of having to be hospitalized for Covid-19 decreased by 92 percent with Moderna and 85 percent with Biontech/Pfizer over the entire study period.

Individual risk of infection was reduced by 86 percent with the Moderna vaccine and 76 percent with the Biontech/Pfizer vaccine, also over the study period.

However, in July, protection against infection fell to 76 percent for Moderna and 42 percent for Biontech/Pfizer.

Data were examined from 25,000 people in each of the U.S. states of Minnesota who had received the Biontech/Pfizer or Moderna vaccines.

Awaiting more data
It is possible that the decline in efficacy has to do with the advance of the Delta variant. However, other studies show a smaller decline in efficacy over time, although comparisons are difficult, in part because of methodological differences in the studies.

And the differences between Biontech/Pfizer and Moderna also need to be confirmed by further studies.

What is clear from the studies, however: The unvaccinated have the greatest risk of infection.

  • source: kurier.at/picture: pixabay.com
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