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According to a new study, it doesn’t matter which vaccine is administered at the 3rd sting – the vaccination works.
According to current knowledge, three partial vaccinations are needed for adequate protection against Covid-19. Pretty much no matter what the third vaccination is given with, the effect is good. That’s according to a new study in the United Kingdom of seven vaccines (six of them approved or still in development), which has now been published in the medical journal The Lancet.
“Six different Covid 19 boosters are safe and induce strong immune responses in people who have previously received two part vaccinations with AstraZeneca or BioNTech/Pfizer,” the Lancet says. Alasdair Munro (University Hospital of Southampton) and his co-authors enrolled 2,878 people in the CoV Boost study throughout June of this year. These were individuals either at a median age of 51 or 53 years or at a median age of 76 or 78 years. They had been vaccinated through with the AstraZeneca or BioNTech/Pfizer vaccines.
Subsequently, subjects received the third vaccination with AstraZeneca, or BioNTech/Pfizer, Novavax vaccine (now just preapproval in the EU), Johnson vaccine (vector), Moderna (mRNA), Valneva vaccine (inactivated Covid-19 pathogens), which is still in development, or Curevac’s now-defunct mRNA vaccine. “The side effect data for all seven vaccines show safety with acceptable inflammatory reactions at the injection site, muscle pain and fatigue,” said Saul Faust of the University Hospital of Southampton.
The third dose of the vaccine had been administered to the participants in the study ten to twelve weeks after the first vaccination. An increase in antibodies to the SARS-CoV-2 spike protein was registered in all groups of those studied. However, the increase was different compared to the control group without further vaccination after AstraZeneca (increase by 1.8- to 32.3-fold) or after Pfizer/BioNTech vaccination (increase by 1.3- to 11.5-fold), depending on the vaccine used for the third prick.
However, the scientists point out that there is currently no sharp threshold in the concentration of antibodies in the blood after Covid-19 vaccination above which safe protection can be assumed. This is even more problematic in the case of the so-called cellular immune response. Here, vaccination for SARS-CoV-2 produces “specialized” immune cells, which contribute just as much to protection. In any case, it appears that the third vaccinations can be administered with either the same or a different vaccine than the first two partial vaccinations.
— source: heute.at/picture: pixabay.com
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